Carvedilol Drug uses, Carvedilol Drug Generic/Brand Names, Carvedilol Drug/Category, Carvedilol
Drug/Indications, Dosage, Mechanism of Action, Side Effects, Precautions.
Image source: Carvedilol Oral tablets
Generic name: Carvedilol
Brand name: Carca, Caditone, Cardivas, Carloc, Carvas, Carvedil, Carvetrend, Carvil, Carvipress, Caslot, Vedilol.
Category/class: Beta- blocker’s.
Carvedilol Use: It is an arylethanolamine non-specific β- adrenoreceptor antagonist with Alpha-blocking activity. It uses anti-hypertensive effect partly by reducing total peripheral resistance and vasodilation by blocking Alpaha-adrenoreceptors and by inhibiting β-adrenoreceptor-mediated compensatory mechanisms.
Indications: Hypertension and congestive heart failure, Chronic stable angina, Ventricular dysfunction, Post myocardial infraction.
(*TD = 3 Times a day*)
(*OD = Once a day*)
(*BD = Twice a day*)
Route of Administration:
May be taken with or without food— Oral, IV, IM
Frequency: Once a day (OD), twice a day / 2 Times a day (BD), 3 Times a day (TD)
Contraindications : Hypersensitivity, Patients with NYHA class IV decompensated cardiac failure requiring IV inotropic therapy, bronchial asthma, second or third-degree AV block, Sick Sinus syndrome, cardiogenic shock or severe bradycardia, hepatic impairment, lactation.
Special Precautions: Before starting the treatment, laboratory confirmation of liver injury is very much essential. Abrupt withdrawal of B-blockers may result in exacerbation of the symptoms of hyperthyroidism. During the initiation of therapy, avoid driving or operating machinery.
Pregnancy Category: C
Side-effects: Increased sweating, fatigue, edema, bradycardia, hypotension (including postural), hyperglycemia, hypercholesterolemia, bronchitis, insomnia, impotency, skin reactions, tinnitus, anemia and even sudden death.
Mechanism of action:- Carvedilol acts by inhibiting the beta adrenergic receptors on cardiac myocytes enabling a lack of response to the sympathetic nervous system and resulting in decreased heart rate. It also blocks the activity alpha-1 receptors to cause vasodilation of blood vessels causing in decreased peripheral vascular resistance.
Adverse Drug Reactions:-
Angina, anemia, bradycardia, Diabetes mellitus, Hypertension, insomnia, thrombocytopenia, Bronchospasm, Seizures, Peripheral edema, Renal Insufficiency, Hyperkalemia, Respiratory alkalosis.
»BP in standing
»Blood glucose levels
»CBC, Heart rate, ECG
»Liver and Renal function.
»Advise patient to take with food to avoid the risk of orthostatic hypotension.
»Advise patient to against sudden documentation of the drug.
»Warn patient to avoid consumption of alcohol during the therapy.
»Advice diabetes to carefully monitor blood sugar levels.
Carvedilol Major Interactions:-
Contact your doctor before using carvedilol with aminophylline. Using these medicines together can make carvedilol less effective and rise the effects of aminophylline. Consult your doctor if you have any experience of nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing. If your doctor does recommend these medicines composed, you may require a dose change or safely use both medicines.
Use carvedilol and clonidine composed may lower your blood pressure and slow your heart rate. Contact your doctor if you have experience of slow heartbeat, headaches, dizziness, or feeling like you might pass out. You may require a dose adjustment or need your blood pressure checked regularly and safely use both medicines.
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