Clonidine Drug uses, Generic/Brand Names, Category, Indications, Dosage, Mechanism of Action, Side Effects, Precautions.
Generic Name: Clonidine
Brand Names: Arkamin, Catapres-Diu, Cloneon, Clonpet, Clothalton,.
Category / Class: Antihypertensives.
All grades of hypertension (except pheochromocytoma).
Its major haemodynamic effects result from action on central sites in medulla (vasomotor center) and hypothalamus. It stimulates alpha 2 receptors present at these sites leading to decrease in sympathetic outflow, resulting in -fall in BP and bradycardia.
(*OD= Once a Day*)
(* BD= Twice a day/ 2 Times a day*)
(*TD= 3 Times a day*)
Hypertension Uses Adult Dose:
Initial dose: 0.1 mg OD 2 times a day
Maintenance dose: 0.2 to 0.6 mg oral OD
Maximum dose: 2.4 mg oral OD
Initial dose: 0.1 mg/24 hour patch applied every 7 days
Maximum dose: 0.3 mg/24 hour patches applied every 7 days
Pain Uses Adult Dose:
Initial dose: 30 mcg/hour as a continuous infusion
Maximum dose 40 mcg/hour as a continuous infusion
Attention Deficit Disorder Uses Pediatric Dose:
6 years and older:
Initial dose: 0.1 mg oral at bedtime
Maximum dose: 0.4 mg/day in 2 divided doses.
Route of Administration:-
May be taken with or without food- Oral, IV
Once a day (OD), twice a day / 2 Times a day (BD), 3 Times a day (TD)
While discontinuing, reduce dose gradually, abrupt withdrawal in patients on high doses may result in severe rebound hypertension.
Pregnancy Category C
Drug passes into the breast milk, not recommended.
Adverse Drug Reaction’s (ADR’s):-
Hypotension, bradycardia, CNC depression, respiratory depression, xerostomia, sinus bradycardia, constipation,
Sedation, dry mouth, dizziness, constipation, sleep disturbances, impotence & allergic manifestations.
Mechanism of Action:-
Clonidine animates alpha2-adrenoceptors in the mind stem, therefore initiating an inhibitory neuron, bringing about diminished thoughtful surge from the CNS, creating an abatement in fringe obstruction, renal vascular opposition, pulse and circulatory strain, epidural clonidine may deliver help with discomfort at spinal presynaptic and postjunctional alpha2-adrenoceptors by forestalling torment signal transmission, relief from discomfort happens just for the body locales innervated by the spinal sections where pain relieving groupings of clonidine exist
For the treatment of ADHD, the component of activity is obscure, it has been recommended that postsynaptic alpha2-agonist incitement controls subcortical action in the prefrontal cortex, the territory of the mind answerable for feelings, considerations, and practices and causes diminished hyperactivity, indiscretion, and distractibility. Epidurally regulated clonidine produces portion subordinate absense of pain not irritated by sedative opponents.
The absense of misery is limited to the body districts innervated by the spinal bits where torment reducing centralizations of clonidine are open Clonidine is thought to make absense of pain at presynaptic and postjunctional alpha-2-adrenoceptors in the spinal string by forestalling torment signal transmission to the cerebrum.
General Considerations Administration:
- IM: May administer undiluted by IM injection.
- IV: Administer diluted IV injection slowly over 5 to 15 minutes. • Oral: May possibly be taken with or without food.
Topical: Transdermal patch should be applied weekly at a consistent time to a clean, hairless area of the upper outer arm or chest. Rotate patch sites weekly. Irritation under patch may be reduced if a topical corticosteroid spray is applied to the area before placement of the patch.
Request of any utilized or unexploited fixes by collapsing glue closes together, supplant in pocket or fixed compartment, and dispose of appropriately in rubbish away from children and pets.
Epidural: Specific methods are required for nonstop epidural organization; organization through this course should just be performed by qualified people acquainted with the strategies of epidural organization and patient administration problems associated with this route.
Familiarization of the epidural infusion device is essential. Do not discontinue clonidine shortly; if needed, this route. Familiarization of the epidural infusion device is essential.
Try not to stop clonidine suddenly; if necessary, progressively diminish portion more than 2 to 3 days to stay away from withdrawal side effects.
Blood pressure (standing and sitting/supine), mental status, heart rate Epidural: Carefully monitor infusion pump, inspect catheter tubing for obstruction or dislodgement to reduce risk of inadvertent abrupt withdrawal of infusion.
• Monitor closely for catheter-related infection (e.g. meningitis or epidural abscess)
If you have any questions and complaints and more information for consult your “Family Doctor” or “Personal “Doctor”.
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