Labetalol Drug Uses, Precautions, Side Effects, Drug Interactions ADR’s

Labetalol cover page

Labetalol Drug uses, Generic/Brand Names, Labetalol Drug /Category, Labetalol Drug /Indications, Labetalol Drug

/Dosage,  Mechanism of Action, Precautions, Side Effects,  Labetalol Drug/Drug-Drug interactions.


Labetalol drug

Image Source: Labetalol Tablets 100Mg USP

Generic name: Labetalol

Brand name: Ab-lol,Cebalol, Labebet,Labesol,Labeta,Labil,Tiplab,Zybelol,Talobet

Category/class: Beta- blocker’s.

Labetalol Use: It is unique among adrenergic antagonists in blocking both a and b receptors. Labetalol is orally effective and undergoes considerable first pass metabolism.

Indications: All grades of hypertension. Especially useful in pheochromocytoma and clonidine withdrawal hypertension.


Image source: Labetalol Hcl Injection 100mg/20ml USP


(*TD = 3 Times a day*)

(*OD = Once a day*)

(*BD = Twice a day*)

Labetalol dosage

Route of Administration:

May be taken with or without food— Oral, IV, IM

 Frequency: Once a day (OD), twice a day / 2 Times a day (BD), 3 Times a day (TD)

Contra-Indications: Children, allergic disorders with predisposition to bronchospasm, right ventricular failure, secondary to pulmonary hypertension. A.V. block greater than 1st degree, pregnancy, lactation, bradycardia, shock, CHF, anesthesia with agents producing myocardial depression.

Special Precautions: Abrupt withdrawal, diabetes, cardiac failure, anesthesia, hyperthyroidism, postural hypotension, eye and skin reaction, liver dysfunction.

Pregnancy Category: C

Side-effects: Failure of ejaculation in males, headache, angina, jaundice, dreams, nightmares.

Mechanism of action:

Labetalol, a mixed alpha/β- adrenergic antagonist, inhibits the adrenaline stimulation of alpha-1 receptors & β-receptors resulting in decreased blood pressure. Labetalol can also decrease sodium entry to decrease the action potential fairing.

Adverse Drug Reactions:-

Edema, hypotension, dyspnea, bronchospasm, diabetes insipidus, arrhythmia.

Monitoring Parameter’s:-

»Blood Pressure, CBC, Cardiac output.

»Renal and Hepatic function.

General Considerations:-

»Educate patient to take immediately after food

»Counsel patient to refrain from driving or performing heavy activities while taking this drug.

»Advise patient against sudden stopped of drug.

Drug-Drug Interactions:-

Labetalol Major Interactions:


Using labetalol together with albuterol reduce the benefits of both medications, since they have opposing effects in the body. In adding, labetalol can sometimes cause narrowing of the airways, which may aggravate your breathing problems or activate severe asthmatic attacks. Labetalol is not recommended if you have chronic obstructive pulmonary disease (COPD), asthma, a history of asthma. Contact your doctor if you have any questions or complaints.


Using labetalol and clonidine may lower your blood pressure and slow your heart rate. If you have any experience of symptoms like slow heartbeat, feeling like you might pass out, headaches, dizziness. You may require a dose change or regularly blood pressure checked ang safely use both medicines.


Using labetalol and diltiazem together may lead to increased side effects. This can cause fatigue, headache, fainting, and swelling of the extremities, shortness of breath, weight gain, chest pain, increased or uneven heartbeat or decreased heartbeat. You may need a dose change or frequently your blood pressure checked and safely use both medicines.

Read More Drug Interactions


I love sharing basic knowledge occurs when people are honestly interested in helping each other develop new experiences learning processes.

If you have any questions and complaints and more information for consult your “Family Doctor” or “Personal “Doctor”.

Please leave a comment!

Thank you.

Leave a Reply

Your email address will not be published. Required fields are marked *