Quinidine Drug Uses, Precautions, Side Effects, Drug Interactions ADR’s

Quinidine Drug uses, Generic/Brand Names, Quinidine Drug/Category, Quinidine Drug/Indications, Quinidine

Drug/Dosage, Mechanism of Action, Side Effects, Precautions, Quinidine Drug/Drug-Drug interactions.

QUINIDINE

Quinidine drug

Image Source: Quinidine Sulphate Tablets 200Mg Usp

Generic name: Quinidine

Brand name:  Quinora,Natcardine, Cardioquin,

Category/class: Antiarrhythmic’s, Antimalarials

Quinidine Use: it is an alkaloid from cinchona bark-the dextroisomer of quinidine and has been noted to suppress rebellious palpitation Quinidine increases the threshold for excitation and reduces conduction velocity , thus limits the spread of arrhythmia and sometimes use malaria.

Indications: Atrial fibrillation or flutter, paroxysmal supra ventricular tachycardia ventricular premature rhythms and ventricular tachycardia. Maintenance of sinus rhythm following electro conversion.

Image Source: Quinidine gluconate Extended-release Tablets 324Mg USP Sunpharmaceuticals




Dosage:

 (*TD = 3 Times a day*)

(*OD = Once a day*)

(*BD = Twice a day*)

Arrhythmias Adult dose:-

Quinidine sulfate Tablets: 100-600 mg oral every 4-6 hours

Begin Dose: 200 mg (maximum daily dose: 3-4 g)

Extended Release:  Quinidine gluconate 324-648 mg oral every 8-12 hours or (Quinidine sulfate) 300-600 mg oral every 8-12 hours.
Intravenous dose: quinidine gluconate 800 mg IV OD

Malaria Adult dose:-
Dosage Regimen 1:
Loading dose: quinidine gluconate -24 mg/kg  OD Oral
Maintenance dose: quinidine gluconate 12 mg/kg Oral OD

Dosage Regimen 2:
Loading dose: quinidine gluconate 10 mg/kg oral OD.
Maintenance dose: quinidine gluconate 0.02 mg/kg Oral OD

Pediatric Malaria dose:-

Dosage Regimen 1:
Loading dose: quinidine gluconate 24 mg/kg 4 hours. Oral OD
Maintenance dose: quinidine gluconate 12 mg/kg OD

Dosage Regimen 2:
Loading dose: quinidine gluconate 10 mg/kg Oral OD

Maintenance dose: quinidine gluconate 0.02 mg/kg Oral OD

Route of Administration:

May be taken with or without food— Oral, IV, IM

Frequency: Once a day (OD), twice a day / 2 Times a day (BD), 3 Times a day (TD)

Contraindications :myasthenia gravis, intolerance or idiosyncrasy to quinidine, heart block, Congestive heart failure, hypotensive states, history of embolism .

Special Precautions: Renal dysfunctions.

Pregnancy Category: C

Side-effects: Nausea, dissociation, vomiting, diarrhea, vertigo, headache, visual disturbances, angioedema, asthma, vascular collapse.



Mechanism of action:-

Antiarrhythmic action:– Decreases myocardial excitability, myocardial contractility, and conduction velocity by decreased sodium influx during repolarization and potassium efflux in during repolarization. The drugs also decrease calcium transport across cell membrane.

Antimalarial action:- the drug act primarily as an intra-erythrocytes’ schizonticide. It also exhibits gametocidal activity against plasmodium vivax and plasmodium malaria

Adverse Drug Reactions:-

Hypersensitivity reaction, autoimmune & inflammatory syndromes, hypotension, hepatotoxicity, diplopia, nyctolopia, angina,

Monitoring Parameter’s:-

»Serum creatinine concentration, electrolyte levels, serum drug concentration.

»Complete blood count , ECG.

General Considerations:-

»Advise patient to avoid large changes in dietary salt intake.

»Advise patient to grapefruit juice.

»Warn patient to avoid consumption of alcohol during the therapy.

Quinidine Major Interactions:

Quinidine + Adenosine:-

Combination of these drugs can increase the risk of an irregular heart rhythm that may be severe and potentially life-threatening, while it is a relatively rare side result. You may require a dose change or more frequent observing by your doctor to safely use both medicines.

Quinidine + Azithromycin:-

Using Quinidine with azithromycin can raise the risk of an irregular heart rhythm that may be serious and possibly life-threatening, while it is a relatively rare side effect. Contact your doctor if you have any experience of   lightheadedness, fainting, shortness of breath, dizziness, and heart palpitations. Consult your doctor if you have any questions or complaints.

Quinidine + Bepridil:-

Using bepridil with Quinidine is not recommended. Combining these drugs can increase the risk of an irregular heart rhythm that may be serious. If you have experience of  fainting ,dizziness, lightheadedness, or fast or defeat heartbeats during management.

Read More Drug Interactions



Conclusion:-

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If you have any questions and complaints and more information for consult your “Family Doctor” or “Personal “Doctor”.

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Post Author: surya20

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